Photochemiluminescent detection of antiradical activity. VI. Antioxidant characteristics of human blood plasma, low density lipoprotein, serum albumin and amino acids duringin vitro oxidation

Luminescence ◽  
1999 ◽  
Vol 14 (3) ◽  
pp. 169-174 ◽  
Author(s):  
I. Popov ◽  
G. Lewin
Keyword(s):  
Amino Acids ◽  
Serum Albumin ◽  
Blood Plasma ◽  
Human Blood ◽  
Antiradical Activity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Blood Plasma ◽  
Low Density ◽  
Antioxidant Characteristics

scholarly journals Atherogenic modification of low-density lipoproteins

2016 ◽  
Vol 62 (4) ◽  
pp. 391-402 ◽  
Author(s):  
V.N. Sukhorukov ◽  
V.P. Karagodin ◽  
A.N. Orekhov
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Lipid Accumulation ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Blood Plasma ◽  
Low Density ◽  
Modified Ldl ◽  
Intracellular Lipid Accumulation

One of the first manifestations of atherosclerosis is accumulation of extra- and intracellular cholesterol esters in the arterial intima. Formation of foam cells is considered as a trigger in the pathogenesis of atherosclerosis. Low density lipoprotein (LDL) circulating in human blood is the source of lipids accumulated in the arterial walls. This review considered features and role in atherogenesis different modified forms of LDL: oxidized, small dense, electronegative and especially desialylated LDL. Desialylated LDL of human blood plasma is capable to induce lipid accumulation in cultured cells and it is atherogenic. LDL possesses numerous alterations of protein, carbohydrate and lipid moieties and therefore can be termed multiple-modified LDL. Multiple modification of LDL occurs in human blood plasma and represents a cascade of successive changes in the lipoprotein particle: desialylation, loss of lipids, reduction in the particle size, increase of surface electronegative charge, etc. In addition to intracellular lipid accumulation, stimulatory effects of naturally occurring multiple-modified LDL on other processes involved in the development of atherosclerotic lesions, namely cell proliferation and fibrosis, were shown.

Atherogenic modification of low density lipoprotein by human blood plasma trans-sialidase

2001 ◽  
Vol 2 (2) ◽  
pp. 103
Author(s):  
V.V. Tertov ◽  
V.V. Kaplun ◽  
K.A. Boytsova ◽  
N.V. Bovin ◽  
A.N. Orekhov
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Blood Plasma ◽  
Low Density

scholarly journals Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women

2000 ◽  
Vol 279 (2) ◽  
pp. R461-R467 ◽  
Author(s):  
Jae-Hak Moon ◽  
Ritsuko Nakata ◽  
Syunji Oshima ◽  
Takahiro Inakuma ◽  
Junji Terao
Keyword(s):  
Blood Plasma ◽  
Low Density Lipoprotein ◽  
Copper Ion ◽  
Density Lipoprotein ◽  
Tocopherol Content ◽  
Human Blood Plasma ◽  
Short Term ◽  
Beneficial Effects ◽  
Human Volunteers ◽  
Conjugated Metabolites

Quercetin is a typical flavonoid present mostly as glycosides in plant foods; it has attracted much attention for its potential beneficial effects in disease prevention. In this study, we examined human volunteers after the short-term ingestion of onion, a vegetable rich in quercetin glucosides. The subjects were served diets containing onion slices (quercetin equivalent: 67.6–93.6 mg/day) with meals for 1 wk. Quercetin was only found in glucuronidase-sulfatase-treated plasma, and its concentration after 10 h of fasting increased from 0.04 ± 0.04 μM before the trial to 0.63 ± 0.72 μM after the 1-wk trial. The quercetin content in low-density lipoprotein (LDL) after glucuronidase-sulfatase treatment corresponded to <1% of the α-tocopherol content. Human LDL isolated from the plasma after the trial showed little improvement of its resistance to copper ion-induced oxidation. It is therefore concluded that conjugated metabolites of quercetin accumulate exclusively in human blood plasma in the concentration range of 10−7 ∼ 10−6 M after the short-term ingestion of vegetables rich in quercetin glucosides, although these metabolites are hardly incorporated into plasma LDL.

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